The guidelines [1] on using methacholine challenge testing (MCCT) to evaluate for airway hyperresponsiveness (AHR), published in 2000, provided a figure that allowed clinicians to calculate posttest ...

Obesity is associated with increased prevalence and incidence of asthma, but the mechanism is unknown. Obesity reduces lung volumes, which can increase airway responsiveness, and increases resistive ...

Background Methacholine hyperresponsiveness is prevalent in elite athletes. Comparative studies have hitherto been limited to methacholine, eucapnic voluntary hyperpnoea and exercise. This study ...

Asthma is characterized pathologically by structural changes in the airway, termed airway remodeling. These changes are associated with worse long-term clinical outcomes and have been attributed to ...

In asthma, the airways become hyperresponsive. Researchers have found a new mechanism that contributes to, and explains, airway hyperresponsiveness. In asthma, the airways become hyperresponsive.