The effectiveness of non-clinical drug safety predictions is enhanced by the adoption of three-dimensional (3D) cellular models. 3D bioprinting enables the generation of complex models with spatial ...

In a bid to gain further understanding of the etiology and pathogenesis of metabolic dysfunction–associated steatohepatitis (MASH), a team of researchers has created 3D bioprinted liver models. MASH, ...

Metabolic dysfunction--associated steatohepatitis or MASH (formerly known as nonalcoholic steatohepatitis) is an inflammatory, liver-scarring disease that affects 1.5% to 6.5% of all U.S. adults.

Drug-induced liver injury induced by already approved substances is a major threat to human patients, potentially resulting in drug withdrawal and substantial loss of financial resources in the ...

Liver transplantation is the primary treatment option for people with end-stage liver disease 1. However, one major barrier to the increased prevalence of liver transplantation is the absence of ...

Metabolic dysfunction- associated steatohepatitis, or MASH, is an inflammatory, liver-scarring disease that has reached epidemic proportions, with an estimated 1.5% to 6.5% of U.S. adults afflicted by ...

A liver cancer diagnosis frequently leads to surgery, with the goal of completely removing all malignant tissue. To ensure ...

The liver is the body's control tower for metabolism, powering vital functions like converting nutrients to glucose, storing fat and breaking down toxins. Over a third of the world, however, is ...

Human periportal assembloid, showcasing the three key cell types of the liver: portal fibroblasts (magenta), cholangiocytes (green), and hepatocyte nuclei (blue). All cell borders are delineated in ...

A US biotechnology company has 3D printed a tiny functioning liver in the lab that survived just over five days -- more than twice the life expectancy of 2D versions. Presenting the results at the ...

A stained micrograph of 3D primary human liver cell tissue modeling MASH. Areas of fibrosis are indicated in blue. Image courtesy of Viscient Biosciences. Metabolic dysfunction- associated ...

Metabolic dysfunction-associated steatohepatitis, or MASH, is an inflammatory, liver-scarring disease that has reached epidemic proportions, with an estimated 1.5% to 6.5% of U.S. adults afflicted by ...