Our skin and mucous membranes are protected by epithelial cells. This barrier tissue performs its function thanks to specialized structures called junctions. They ensure cell cohesion and regulate ...

Epithelial cells establish and maintain an apical–basal axis that underpins tissue organisation, directional transport and barrier function across organs. This polarity arises through coordinated ...

In pink, wild type cells expressing gamma actin. In black, knock-out cells that do not express gamma actin. The yellowish lines reveal the tortuous nature of the junctions. Our skin and mucous ...

Cryo-electron tomography (cryoET) provides sub-nanometer protein structure within the dense cellular environment. Existing sample preparation methods are insufficient at accessing the plasma membrane ...